Research in the Zemper Lab focuses on small intestinal and colonic epithelial stem cell behavior. There are several unique populations of progenitor cells within the colonic crypt, and it is posited that each has a unique ability to differentially regulate intestinal homeostasis. These populations are marked by a number of different proteins and have different proliferative properties. The dynamic nature of these intestinal stem cells is likely exploited in normal process of development or repair after injury, but also in malignant transformation.